Management of those at increased risk of malignancy

Management of those at increased risk of malignancy
because of a family history is based on screening. Annual
mammography between ages 35 and 50 is suggested for women
at 1 in 6 or greater risk of breast cancer, and annual
transvaginal ultrasound for those at 1 in 10 or greater risk of
ovarian cancer. In HNPCC (as in the general population), all
bowel malignancy arises in adenomatous polyps, and regular
colonoscopy with removal of polyps is offered to people whose
risk of bowel cancer is 1 in 10 or greater. The screening interval
and any other screening tests needed are influenced by both
the pedigree and tumour characteristics.